Steve Gerber, and comics legend Jack Kirby did production design. With a striking visual style and beautiful animation, this is one that you cannot miss. It shows on the Boomerang channel quite a bit, so keep an eye out for it.
Buck Rogers in the 25th Century - Starring Gil Gerard, this series ran from the end of the 70s into the early 80s. Developed by Gary Larson, who later went on to create Battlestar Galactica, the show was an update of the classic comic strip from the 1920s. The original TV pilot/movie was a bit different than the "swashbuckler in space" show it became. In the pilot, Earth has been destroyed by nuclear war, and the remains of civilization live in insular cities. Buck Rogers, reawakened after hundreds of years in cryostasis, wanders outside the clean confines of New Chicago into the ruins of the shattered city. There he is attacked by a band of hideously deformed mutants who live in there. They chase him through the streets until he gets to a graveyard, where he is saved in the nick of time. Overall, the movie was better than the show, and this scene had a big part in that. I wish they had kept that around for the series.
The Last Man on Earth - I mentioned this in reference to Omega Man, but this is the best of the adaptations of Richard Matheson's I Am Legend. Even though Matheson himself didn't care for it and had his name removed from the credits, it was a stark, unflinching portrayal of the horror that comes from the notion of the world having moved on and left you behind. The ending was wonderfully bleak, and the black and white footage was an inspiration for George Romero when it came time for him to create the Night of the Living Dead. It's in the public domain at this point, so it should be easy to find.