It was a bit weird at first - they're designed for Pathfinder games, and so some of the stuff was lost in translation. We figured out ways around it though, such as when the party caught a critical hit which called for Intelligence Bleed. It required a bit of fudging when it was inflicted upon a Stone Giant, we ended up deciding that it had an Intelligence of 10, and when it bled out, it was dead.
But oh, the Critical Fumbles. Hilarity ensued as the dwarven cleric knocked himself out after smashing himself in the foot with a hammer and bleeding out, the elven archer tore a muscle and notched her fingers, causing bleed damage and penalties to hit, etcetera, etcetera, etcetera...
The party seemed to get into it as well, even if there were far more cards drawn from the fumble deck than the hit deck. So yeah, all around success.
They're available here, along with other types of cards of dubious usefulness - http://paizo.com/gameMastery/itemPacks
I'll have to give these a go some time. I have them, but haven't used them.
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